The California Office of Environmental Health Hazard Assessment established a 5 parts per billion hexavalent chromium health protective concentration standard which serves as a scientific benchmark yet functions as an initial regulatory alert that manufacturing firms and compliance departments and enterprise risk management groups must address. Organizations operating in electronics and industrial manufacturing and metal processing and construction and global supply chains currently experience increasing demands to improve their ability to monitor substances and track supplier information and maintain preparedness for audits because of intensified enforcement of Proposition 65. The current update creates major effects which impact how organizations manage regulatory hazards and develop their compliance framework mappings and assess future exposure risks which relate to their Proposition 65 and REACH and RoHS and TSCA and OSHA responsibilities. Business executives need to assess